PO-02-044 HIS CARDIAC RESYNCHRONIZATION THERAPY: A NETWORK META-ANALYSIS

Cardiac conduction system pacing, in the form of His-Cardiac Resynchronization therapy (His-CRT), is advantageous due to its physiological nature and accompanying clinical benefits.His-CRT has not become mainstream practice, challenges such as higher procedural time, pacing thresholds varying success rates. There a paucity studies comparing His-CRT with other modalities Left Bundle Branch Paced-Cardiac Therapy (LBBP-CRT) or Bi-Ventricular-Cardiac Therapy(BiV-CRT). To investigate electrophysiologic outcomes patients receiving compared LBBP-CRT BiV-CRT. We performed systematic search PubMed, EMBASE, Scopus databases identify BiV-CRT for appropriate indications. Eight were included final analysis. The studied differences ejection fraction (EF), QRS duration, capture threshold ventricular impedance at baseline follow-up. A frequentist network meta-analysis model was used. used netmeta module random effects CRAN-R software compute pooled standard mean across all outcomes. Higgin’s I2 statistic evaluate heterogeneity. Results are reported using reference treatment. Pooled Standard Mean Difference (SMD) follow-up EF comparison - 5.66% (95% CI: -10.6 0.73; p-value = 0.024) while -0.87% -5.53 3.79; 0.714). SMD 13.96 ms 4.21 23.70; 0.005) 1.27 -4.789 7.346; 0.679). 1.03 V 0.69 1.375; < 0.0001) 0.677 0.504 0.8501; 0.0001). -281.25 Ohms 380.24 182.25; -41.33 101.059 18.393; 0.1750). associated better most measured parameters comparable His-CRT. Prospective trials needed further substantiate our findings.